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Impact of Prior Antiplatelet Therapy on Risk of Embolism in Infective Endocarditis
Author(s) -
Namrata S Anavekar,
Imad M. Tleyjeh,
Zaur Mirzoyev,
James M. Steckelberg,
Christelle Haddad,
Masud H. Khandaker,
Walter R. Wilson,
Krishnaswamy Chandrasekaran,
Larry M. Baddour
Publication year - 2007
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/513197
Subject(s) - medicine , infective endocarditis , endocarditis , embolism , bacteremia , intensive care medicine , surgery , antibiotics , microbiology and biotechnology , biology
Embolism is a dreaded complication of infective endocarditis (IE). Currently, antimicrobial therapy is the only medical intervention proven to decrease the risk of embolism associated with IE. We hypothesized that, because platelet aggregation is operative in the pathogenesis of vegetation formation, embolism associated with IE should occur less frequently among patients who have received prior, continuous daily antiplatelet therapy for noninfectious reasons.

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