Plasmodium falciparum–Infected Erythrocytes Decrease the Integrity of Human Blood‐Brain Barrier Endothelial Cell Monolayers | Zendy

Abhai K. Tripathi | Zendy; David J. Sullivan | Zendy; Monique F. Stins | Zendy

Open Access

Plasmodium falciparum–Infected Erythrocytes Decrease the Integrity of Human Blood‐Brain Barrier Endothelial Cell Monolayers

Author(s) -

Abhai K. Tripathi,

David J. Sullivan,

Monique F. Stins

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/512083

Subject(s) - blood–brain barrier , plasmodium falciparum , endothelium , biology , cerebral malaria , endothelial stem cell , occludin , in vitro , red blood cell , barrier function , tight junction , microbiology and biotechnology , immunology , biochemistry , central nervous system , endocrinology , malaria

Central to the pathologic progression of human cerebral malaria (CM) is sequestration of Plasmodium falciparum-infected red blood cells (Pf-IRBCs) to the blood-brain barrier (BBB) endothelium. The molecular interactions between Pf-IRBCs and the BBB endothelium and their implications for barrier function are unclear.

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