The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya | Zendy

Sarah H. Atkinson | Zendy; Tabitha Mwangi | Zendy; Sophie Uyoga | Zendy; Edna Ogada | Zendy; Alexander W. Macharia | Zendy; Kimberly Marsh | Zendy; Andrew M. Prentice | Zendy; Thomas N. Williams | Zendy

Open Access

The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya

Author(s) -

Sarah H. Atkinson,

Tabitha Mwangi,

Sophie Uyoga,

Edna Ogada,

Alexander W. Macharia,

Kimberly Marsh,

Andrew M. Prentice,

Thomas N. Williams

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/511868

Subject(s) - malaria , parasitemia , haptoglobin , genotype , plasmodium falciparum , medicine , incidence (geometry) , immunology , allele , biology , genetics , physics , optics , gene

Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from malaria or other diseases.

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