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Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from malaria or other diseases.

The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya