Influence of HLA Alleles on Shedding of Kaposi Sarcoma–Associated Herpesvirus in Saliva in an African Population | Zendy

Khaled R. Alkharsah | Zendy; Martin Dedicoat | Zendy; Rainer Blasczyk | Zendy; Robert Newton | Zendy; Thomas F. Schulz | Zendy

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Influence of HLA Alleles on Shedding of Kaposi Sarcoma–Associated Herpesvirus in Saliva in an African Population

Author(s) -

Khaled R. Alkharsah,

Martin Dedicoat,

Rainer Blasczyk,

Robert Newton,

Thomas F. Schulz

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/511827

Subject(s) - saliva , allele , human leukocyte antigen , biology , viral load , hla a , immunology , virology , polymerase chain reaction , viral shedding , kaposi's sarcoma associated herpesvirus , population , genotype , virus , genetics , viral disease , medicine , herpesviridae , antigen , gene , environmental health , biochemistry

Kaposi sarcoma-associated herpesvirus (KSHV) is endemic in sub-Saharan Africa. Infection in childhood involves mother-to-child transmission and transmission between siblings or other close contacts. Large amounts of viral DNA in saliva have been linked to transmission from mother to child. To investigate factors contributing to the shedding of KSHV in the saliva of mothers in rural South Africa, we sequenced the HLA-A alleles of 448 mothers and the HLA-DRB1 alleles of 363 mothers and compared their HLA types with viral loads in saliva.

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