Hemorrhagic Hereditary Telangiectasia (Rendu-Osler Disease) and Infectious Diseases: An Underestimated Association | Zendy

Sophie DupuisGirod | Zendy; Sophie Giraud | Zendy; Évelyne Decullier | Zendy; Gaëtan Lesca | Zendy; Vincent Cottin | Zendy; Frédéric Faure | Zendy; O. Merrot | Zendy; J. C. Saurin | Zendy; J.-F. Cordier | Zendy; Henri Plauchu | Zendy

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Hemorrhagic Hereditary Telangiectasia (Rendu-Osler Disease) and Infectious Diseases: An Underestimated Association

Author(s) -

Sophie DupuisGirod,

Sophie Giraud,

Évelyne Decullier,

Gaëtan Lesca,

Vincent Cottin,

Frédéric Faure,

O. Merrot,

J. C. Saurin,

J.-F. Cordier,

Henri Plauchu

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/511645

Subject(s) - medicine , telangiectasia , staphylococcus aureus , disease , dermatology , bacteria , genetics , biology

Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and were associated with prolonged epistaxis. Cerebral infections accounted for 33% of all infections, were mainly due to multiple and anaerobic bacteria, and were associated with the presence of pulmonary arteriovenous malformations and a short duration of epistaxis.

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