Whole‐Blood Interleukin‐18 Level during Early HIV‐1 Infection Is Associated with Reduced CXCR4 Coreceptor Expression and Interferon‐γ Levels | Zendy

Carrie A. Sailer | Zendy; Gregory B. Pott | Zendy; Charles A. Dinarello | Zendy; Samantha Ma Whinney | Zendy; Jeri E. Forster | Zendy; Jacqueline K. LarsonDuran | Zendy; Alan Landay | Zendy; Lena AlHarthi | Zendy; Robert T. Schooley | Zendy; Constance A. Benson | Zendy; Franklyn N. Judson | Zendy; Melanie Thompson | Zendy; Frank J. Palella | Zendy; Leland Shapiro | Zendy

Open Access

Whole‐Blood Interleukin‐18 Level during Early HIV‐1 Infection Is Associated with Reduced CXCR4 Coreceptor Expression and Interferon‐γ Levels

Author(s) -

Carrie A. Sailer,

Gregory B. Pott,

Charles A. Dinarello,

Samantha Ma Whinney,

Jeri E. Forster,

Jacqueline K. LarsonDuran,

Alan Landay,

Lena AlHarthi,

Robert T. Schooley,

Constance A. Benson,

Franklyn N. Judson,

Melanie Thompson,

Frank J. Palella,

Leland Shapiro

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/511435

Subject(s) - human immunodeficiency virus (hiv) , interferon , immunology , cxcr4 , virology , biology , interleukin , medicine , cytokine , microbiology and biotechnology , immune system , chemokine

Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)- gamma levels. By contrast, a direct association between IL-18 and IFN- gamma levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

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