Persistence of K103N‐Containing HIV‐1 Variants after Single‐Dose Nevirapine for Prevention of HIV‐1 Mother‐to‐Child Transmission | Zendy

Tamara Flys | Zendy; Deborah Donnell | Zendy; Anthony Mwatha | Zendy; Clemensia Nakabiito | Zendy; Philippa Musoke | Zendy; Francis Mmiro | Zendy; J. Brooks Jackson | Zendy; Laura Guay | Zendy; Susan H. Eshleman | Zendy

Open Access

Persistence of K103N‐Containing HIV‐1 Variants after Single‐Dose Nevirapine for Prevention of HIV‐1 Mother‐to‐Child Transmission

Author(s) -

Tamara Flys,

Deborah Donnell,

Anthony Mwatha,

Clemensia Nakabiito,

Philippa Musoke,

Francis Mmiro,

J. Brooks Jackson,

Laura Guay,

Susan H. Eshleman

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/511433

Subject(s) - nevirapine , persistence (discontinuity) , virology , lentivirus , transmission (telecommunications) , human immunodeficiency virus (hiv) , medicine , viral load , viral disease , antiretroviral therapy , geotechnical engineering , electrical engineering , engineering

K103N-containing human immunodeficiency virus (HIV)-1 variants are selected in some women who receive single-dose (SD) nevirapine (NVP) for prevention of HIV-1 mother-infant transmission. We examined the persistence of K103N in women who received SD NVP prophylaxis. K103N was detected using the LigAmp assay (assay cutoff, 0.5% K103N). K103N was detected at 6-8 weeks in 60 (41.7%) of 144 women. Fading (lack of detection) of K103N was documented in 16 women by 2 years, 43 women by 3 years, and 55 women by 4 and 5 years. Slower fading was independently associated with HIV-1 subtype (D>A) and higher pre-NVP viral load.

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