Open AccessInfection withTrichomonas vaginalisIncreases the Risk of HIV‐1 Acquisition
Author(s) -
R. Scott McClelland,
Laura Sangaré,
Wisal Hassan,
Ludo Lavreys,
Kishorchandra Mandaliya,
James Kiarie,
Jeckoniah NdinyaAchola,
Walter Jaoko,
Jared M. Baeten
Publication year - 2007
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/511278
Subject(s) - trichomonas vaginalis , trichomoniasis , medicine , trichomonas vaginitis , confidence interval , confounding , human immunodeficiency virus (hiv) , prospective cohort study , genital tract , gynecology , immunology , sida , obstetrics , sexually transmitted disease , viral disease , physiology , syphilis
We conducted a prospective study among women in Mombasa, Kenya, to determine whether Trichomonas vaginalis infection was associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) infection. At monthly follow-up visits, laboratory screening for HIV-1 and genital tract infections was conducted. Among 1335 HIV-1-seronegative women monitored for a median of 566 days, there were 806 incident T. vaginalis infections (23.6/100 person-years), and 265 women seroconverted to HIV-1 (7.7/100 person-years). Trichomoniasis was associated with a 1.52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women.
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