Estrogen Increases Menopausal Host Susceptibility to Experimental Ascending Urinary‐Tract Infection | Zendy

Edward M. Curran | Zendy; Audrey Hart–Van Tassell | Zendy; Barbara M. Judy | Zendy; B. Nowicki | Zendy; Valerie MontgomeryRice | Zendy; D. Mark Estes | Zendy; Stella Nowicki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Estrogen Increases Menopausal Host Susceptibility to Experimental Ascending Urinary‐Tract Infection

Author(s) -

Edward M. Curran,

Audrey Hart–Van Tassell,

Barbara M. Judy,

B. Nowicki,

Valerie MontgomeryRice,

D. Mark Estes,

Stella Nowicki

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/511275

Subject(s) - estrogen , urinary system , escherichia coli , medicine , physiology , endocrinology , biology , urology , biochemistry , gene

The protective effect of estrogen replacement on ascending urinary-tract infection (UTI) is controversial. We designed a study using an experimental model of UTI in which surgically menopausal mice were supplemented with estrogen and the susceptibility to UTI was evaluated after experimental Escherichia coli infection. The mean rate of E. coli infection in the group not treated with estrogen was 2 x 10(4) cfu/g of renal tissue, compared with 9 x 10(8) cfu/g (P<.001) in the estrogen-treated group. Surprisingly, despite the hypothesis that estrogen would protect mice from infection, estrogen treatment significantly increased the susceptibility of the mice to ascending UTI.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research