Human T Lymphotropic Virus Type 1 (HTLV-1) Proviral Load in Asymptomatic Carriers, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis, and Other Neurological Abnormalities Associated with HTLV-1 Infection | Zendy

M.T.T. Silva | Zendy; R. C. Harab | Zendy; Ana Claúdia Celestino Bezerra Leite | Zendy; Doris Schor | Zendy; Abelardo Araújo | Zendy; Maria J. AndradaSerpa | Zendy

Open Access

Human T Lymphotropic Virus Type 1 (HTLV-1) Proviral Load in Asymptomatic Carriers, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis, and Other Neurological Abnormalities Associated with HTLV-1 Infection

Author(s) -

M.T.T. Silva,

R. C. Harab,

Ana Claúdia Celestino Bezerra Leite,

Doris Schor,

Abelardo Araújo,

Maria J. AndradaSerpa

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/510679

Subject(s) - tropical spastic paraparesis , myelopathy , human t lymphotropic virus , medicine , asymptomatic carrier , asymptomatic , virology , human t lymphotropic virus 1 , virus , immunology , viral load , pathology , spinal cord , psychiatry , t cell leukemia

Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.

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