Two Studies Feed the Debate on Active Surveillance for Methicillin‐ResistantStaphylococcus aureusand Vancomycin‐Resistant Enterococci Carriage: To Screen or Not to Screen?
Author(s) -
Thomas R. Talbot
Publication year - 2007
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/510629
Subject(s) - carriage , vancomycin resistant enterococci , microbiology and biotechnology , staphylococcus aureus , vancomycin , methicillin resistant staphylococcus aureus , medicine , enterococcus , virology , biology , antibiotics , bacteria , pathology , genetics
[5] are but a few examples. Two of the more prominent antibiotic-resistant pathogens are methicillin-resistant Staphylococcus aureus (MRSA) and vancomycinresistant enterococci (VRE). According to a recent report from the National Nosocomial Infections Surveillance system of the US Centers for Disease Control and Prevention (CDC), MRSA accounted for nearly 60% of all nosocomial S. aureus infections in intensive care units (ICUs), whereas 29% of enterococcal infections in this population were caused by vancomycin-resistant species [6]. Infection with either pathogen leads to substantial morbidity and mortality, even compared with infection with their antibiotic-sensitive counterparts. MRSA infections have been associated with more prolonged hospitalizations, higher costs, and higher mortality than methicillin-sensitive S. aureus infections [7-10]. VRE, which is sometimes wrongly considered to be a minor pathogen, can also cause substantial morbidity. Bacteremia caused by VRE, after adjustment for severity of illness, is associated with higher recurrence, mortality, and excess costs than vancomycin-sensitive enterococcal infection [11-13]. Individuals can become colonized with
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