Open AccessGroup BStreptococcusBacteremia Elicits β C Protein–Specific IgMand IgG in Humans
Author(s) -
Pia S. Pannaraj,
Joanna K. Kelly,
Lawrence C. Madoff,
Marcia A. Rench,
Catherine S. Lachenauer,
Morven S. Edwards,
Carol J. Baker
Publication year - 2007
Publication title -
the journal of infectious diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/510627
Subject(s) - bacteremia , streptococcus , microbiology and biotechnology , medicine , group b , streptococcus pneumoniae , streptococcaceae , immunoglobulin g , streptococcal infections , immunology , antibody , biology , bacteria , antibiotics , genetics
Group B Streptococcus (GBS) beta C protein elicits protective antibodies in experimental animals, making beta C protein an attractive component of a human GBS glycoconjugate vaccine. We determined whether natural exposure to beta C protein elicits antibodies in humans. Geometric mean concentrations (in micrograms per milliliter) of beta C-specific immunoglobulin (Ig) M and IgG as determined by enzyme-linked immunosorbent assay were similar in serum from 16 colonized (0.82 and 0.76, respectively) and 48 age-matched noncolonized (0.96 and 0.74, respectively) pregnant women. Serum from 3 women with beta C GBS bacteremia had significantly higher levels of IgM (6.0) and IgG (52.9) (P=.01 and 0.01, respectively). Invasive disease but not colonization elicits beta C-specific IgM and IgG.
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