Diversity and Antibiotic Resistance among Nonvaccine Serotypes ofStreptococcus pneumoniaeCarriage Isolates in the Post–Heptavalent Conjugate Vaccine Era | Zendy

William P. Hanage | Zendy; Susan S. Huang | Zendy; Marc Lipsitch | Zendy; Cynthia Bishop | Zendy; Daniel Godoy | Zendy; Stephen I. Pelton | Zendy; Richard Goldstein | Zendy; Heather Huot | Zendy; Jonathan A. Finkelstein | Zendy

Open Access

Diversity and Antibiotic Resistance among Nonvaccine Serotypes ofStreptococcus pneumoniaeCarriage Isolates in the Post–Heptavalent Conjugate Vaccine Era

Author(s) -

William P. Hanage,

Susan S. Huang,

Marc Lipsitch,

Cynthia Bishop,

Daniel Godoy,

Stephen I. Pelton,

Richard Goldstein,

Heather Huot,

Jonathan A. Finkelstein

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/510249

Subject(s) - carriage , streptococcus pneumoniae , serotype , microbiology and biotechnology , virology , antibiotic resistance , biology , pneumococcal conjugate vaccine , antibiotics , medicine , pathology

In response to the selective pressure of pneumococcal conjugate vaccine, increased asymptomatic carriage of antibiotic-nonsusceptible nonvaccine serotypes (NVTs) has been observed. Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clones, and expansion of existing clones.

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