Stage‐Specific Adaptation of HypermutablePseudomonas aeruginosaIsolates during Chronic Pulmonary Infection in Patients with Cystic Fibrosis | Zendy

Michael Hogardt | Zendy; Christina Hoboth | Zendy; Sabine Schmoldt | Zendy; Christine Henke | Zendy; Lutz Bader | Zendy; Jürgen Heesemann | Zendy

Open Access

Stage‐Specific Adaptation of HypermutablePseudomonas aeruginosaIsolates during Chronic Pulmonary Infection in Patients with Cystic Fibrosis

Author(s) -

Michael Hogardt,

Christina Hoboth,

Sabine Schmoldt,

Christine Henke,

Lutz Bader,

Jürgen Heesemann

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/509821

Subject(s) - virulence , pseudomonas aeruginosa , biology , cystic fibrosis , microbiology and biotechnology , genotype , phenotype , lung , serotype , dominance (genetics) , gene , bacteria , genetics , medicine

Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair genes generate numerous bacterial variants because of high mutation rates. In cystic fibrosis (CF), such mutator strains may lead to the rapid selection of survivors that are specifically adapted to the hostile environment of the inflamed CF lung.

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