Blinded Case-Control Study of the Relationship between Human Coronavirus NL63 and Kawasaki Syndrome | Zendy

Samuel R. Dominguez | Zendy; Marsha S. Anderson | Zendy; Mary P. Glodé | Zendy; Christine C. Robinson | Zendy; Kathryn V. Holmes | Zendy

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Blinded Case-Control Study of the Relationship between Human Coronavirus NL63 and Kawasaki Syndrome

Author(s) -

Samuel R. Dominguez,

Marsha S. Anderson,

Mary P. Glodé,

Christine C. Robinson,

Kathryn V. Holmes

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/509509

Subject(s) - kawasaki disease , coronavirus , covid-19 , medicine , virology , cardiology , disease , artery , outbreak , infectious disease (medical specialty)

We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)-NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription-polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.

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