Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial
Author(s) -
Thomas J. Walsh,
Issam Raad,
Thomas F. Patterson,
Pranatharthi Chandrasekar,
Gerald R. Donowitz,
Richard Graybill,
Reginald E. Greene,
Ray Hachem,
Susan Hadley,
Raoul Herbrecht,
Amelia Langston,
Arnold Louie,
Patricia Ribaud,
Brahm H. Segal,
David A. Stevens,
JoAnne H. van Burik,
Charles S. White,
Gavin Corcoran,
Jagadish Gogate,
Gopal Krishna,
Lisa D. Pedicone,
C. Hardalo,
John R. Perfect
Publication year - 2006
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/508774
Subject(s) - posaconazole , medicine , aspergillosis , neutropenia , refractory (planetary science) , voriconazole , salvage therapy , population , transplantation , hematopoietic stem cell transplantation , surgery , gastroenterology , immunology , chemotherapy , antifungal , dermatology , biology , astrobiology , environmental health
Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Current treatments provide limited benefit. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species.
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