Reduced Ability of Penicillin to Eradicate Ingested Group A Streptococci from Epithelial Cells: Clinical and Pathogenetic Implications | Zendy

Edward L. Kaplan | Zendy; G. S. Chhatwal | Zendy; Manfred Rohde | Zendy

Open Access

Reduced Ability of Penicillin to Eradicate Ingested Group A Streptococci from Epithelial Cells: Clinical and Pathogenetic Implications

Author(s) -

Edward L. Kaplan,

G. S. Chhatwal,

Manfred Rohde

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/508773

Subject(s) - penicillin , clindamycin , erythromycin , microbiology and biotechnology , azithromycin , streptococcus pyogenes , antibiotics , intracellular , medicine , viability assay , immunology , biology , cell , bacteria , staphylococcus aureus , biochemistry , genetics

Group A streptococci (Streptococcus pyogenes; GAS) invades human epithelial cell lines. Failure of penicillin to eradicate GAS from the throats of patients, especially those who are GAS "carriers," has been increasingly reported. However, there has been no comprehensive evaluation of how effectively antibiotics that are used to treat GAS enter upper respiratory tract epithelial cells and kill internalized GAS. We examined the viability of ingested, intracellular GAS after epithelial cell exposure to antibiotics commonly recommended for therapy of GAS infections.

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