Open AccessThe Mutant Selection Window in Rabbits Infected withStaphylococcus aureus
Author(s) -
Junchang Cui,
You-ning Liu,
Rui Wang,
Weihang Tong,
Karl Drlica,
Xilin Zhao
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/508752
Subject(s) - levofloxacin , staphylococcus aureus , in vivo , antimicrobial , microbiology and biotechnology , minimum inhibitory concentration , mutant , biology , quinolone , antibiotics , bacteria , biochemistry , genetics , gene
The mutant selection window hypothesis, originally based on agar plate assays, may lead to new antimicrobial dosing strategies that severely restrict the acquisition of resistance. However, it has not been directly tested in an animal model of infection.
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