Lactobacilli Expressing Variable Domain of Llama Heavy‐Chain Antibody Fragments (Lactobodies) Confer Protection against Rotavirus‐Induced Diarrhea | Zendy

Neha Pant | Zendy; Anna Hultberg | Zendy; Yaofeng Zhao | Zendy; Lennart Svensson | Zendy; Qiang PanHammarström | Zendy; Kari Johansen | Zendy; Peter H. Pouwels | Zendy; Franco Maria Ruggeri | Zendy; Pim Hermans | Zendy; Leon Frenken | Zendy; Thomas Borén | Zendy; Harold Marcotte | Zendy; Lennart Hammarström | Zendy

Open Access

Lactobacilli Expressing Variable Domain of Llama Heavy‐Chain Antibody Fragments (Lactobodies) Confer Protection against Rotavirus‐Induced Diarrhea

Author(s) -

Neha Pant,

Anna Hultberg,

Yaofeng Zhao,

Lennart Svensson,

Qiang PanHammarström,

Kari Johansen,

Peter H. Pouwels,

Franco Maria Ruggeri,

Pim Hermans,

Leon Frenken,

Thomas Borén,

Harold Marcotte,

Lennart Hammarström

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/508747

Subject(s) - rotavirus , diarrhea , virology , antibody , recombinant dna , heavy chain , vaccination , biology , immunology , medicine , virus , biochemistry , gene

Rotavirus-induced diarrhea poses a worldwide medical problem in causing substantial morbidity and mortality among children in developing countries. We therefore developed a system for passive immunotherapy in which recombinant lactobacilli constitutively express neutralizing variable domain of llama heavy-chain (VHH) antibody fragments against rotavirus.

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