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Rate of Viral Evolution and Risk of Losing Future Drug Options in Heavily Pretreated, HIV-Infected Patients Who Continue to Receive a Stable, Partially Suppressive Treatment Regimen
Author(s) -
Hiroyu Hatano,
Peter W. Hunt,
Jodi Weidler,
Eoin Coakley,
Rebecca Hoh,
Teri Liegler,
Jeffrey N. Martin,
Steven G. Deeks
Publication year - 2006
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/508655
Subject(s) - medicine , regimen , viral load , drug resistance , population , resistance mutation , protease inhibitor (pharmacology) , cohort , mutation , virology , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , reverse transcriptase , biology , genetics , polymerase chain reaction , environmental health , gene
Many treatment-experienced, HIV-infected patients who have limited therapeutic options for complete viral suppression continue to receive a partially suppressive treatment regimen pending the availability of at least 2 new antiretroviral drugs. The major risk of this approach is ongoing viral evolution and the loss of future drug options.

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