Equal Amounts of Intracellular and Virion‐Enclosed Hepatitis C Virus RNA Are Associated with Peripheral‐Blood Mononuclear Cells In Vivo | Zendy

Philipp Kaiser | Zendy; Barbara Niederöst | Zendy; Béda Joos | Zendy; Viktor von Wyl | Zendy; Milos Opravil | Zendy; Rainer Weber | Zendy; Huldrych F. Günthard | Zendy; Marek Fischer | Zendy

Open Access

Equal Amounts of Intracellular and Virion‐Enclosed Hepatitis C Virus RNA Are Associated with Peripheral‐Blood Mononuclear Cells In Vivo

Author(s) -

Philipp Kaiser,

Barbara Niederöst,

Béda Joos,

Viktor von Wyl,

Milos Opravil,

Rainer Weber,

Huldrych F. Günthard,

Marek Fischer

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/508431

Subject(s) - peripheral blood mononuclear cell , in vivo , virology , hepatitis c virus , virus , intracellular , rna , biology , hepacivirus , immunology , hepatitis c , medicine , in vitro , microbiology and biotechnology , gene , genetics

Hepatitis C virus (HCV) replicating in peripheral-blood mononuclear cells (PBMCs) may represent an extrahepatic viral reservoir. Quantitation of HCV RNA with regard to its subcellular distribution and longitudinal course is needed for better understanding of the largely unexplored in vivo dynamics and potential pathogenetic significance of HCV in PBMCs.

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