Symptomatic Relapse of HIV‐Associated Cryptococcal Meningitis after Initial Fluconazole Monotherapy: The Role of Fluconazole Resistance and Immune Reconstitution | Zendy

Tihana Bicanic | Zendy; Thomas S. Harrison | Zendy; Aliiepieklo | Zendy; tobeko Dyakopu | Zendy; Graeme Meintjes | Zendy

Open Access

Symptomatic Relapse of HIV‐Associated Cryptococcal Meningitis after Initial Fluconazole Monotherapy: The Role of Fluconazole Resistance and Immune Reconstitution

Author(s) -

Tihana Bicanic,

Thomas S. Harrison,

Aliiepieklo,

tobeko Dyakopu,

Graeme Meintjes

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/507895

Subject(s) - fluconazole , medicine , context (archaeology) , cryptococcus neoformans , amphotericin b , meningitis , cryptococcosis , mycosis , antiretroviral therapy , immunology , surgery , human immunodeficiency virus (hiv) , antifungal , viral load , dermatology , paleontology , genetics , biology

Cryptococcal meningitis (CM) in South Africa is often treated with fluconazole as initial therapy. Surveillance data suggest that the prevalence of fluconazole-resistant CM is increasing, and expanding access to antiretroviral therapy is resulting in increasing recognition of immune reconstitution inflammatory syndrome. Therefore, we conducted a study to assess the contribution of these factors to CM relapse in this context.

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