Cross‐Protectiveness and Immunogenicity of Influenza A/Duck/Singapore/3/97(H5) Vaccines against Infection with A/Vietnam/1203/04(H5N1) Virus in Ferrets | Zendy

Aleksandr S. Lipatov | Zendy; Erich Hoffmann | Zendy; Rachelle Salomon | Zendy; HuiLing Yen | Zendy; Robert G. Webster | Zendy

Open Access

Cross‐Protectiveness and Immunogenicity of Influenza A/Duck/Singapore/3/97(H5) Vaccines against Infection with A/Vietnam/1203/04(H5N1) Virus in Ferrets

Author(s) -

Aleksandr S. Lipatov,

Erich Hoffmann,

Rachelle Salomon,

HuiLing Yen,

Robert G. Webster

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/507709

Subject(s) - virology , hemagglutination assay , hemagglutinin (influenza) , virus , immunogenicity , titer , biology , influenza a virus subtype h5n1 , newcastle disease , inactivated vaccine , hemagglutination , microbiology and biotechnology , antibody , immunology

Ferrets were immunized with two 7- mu g doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1) (Viet/1203/04). Serum samples did not react with Viet/1203/04 in hemagglutination-inhibition (HI) or virus-neutralization (VN) tests. All vaccinated ferrets survived the challenge, whereas all mock-immunized ferrets died. Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-severe disease. Vaccine generated from antigenically different H5 virus protects against infection by a highly pathogenic H5 strain. Neither HI nor VN testing provides correlates of cross-protection in ferrets.

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