The Absence of Anti‐Tat Antibodies Is Associated with Risk of Disease Progression in HIV‐2 Infection | Zendy

Shaun K. Rodriguez | Zendy; Abdoulaye Dieng Sarr | Zendy; Olushola Olorunnipa | Zendy; Stephen J. Popper | Zendy; Aïssatou GuèyeNdiaye | Zendy; Ibrahima Traoré | Zendy; M. Dia | Zendy; Souleymane Mboup | Zendy; Phyllis Kanki | Zendy

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The Absence of Anti‐Tat Antibodies Is Associated with Risk of Disease Progression in HIV‐2 Infection

Author(s) -

Shaun K. Rodriguez,

Abdoulaye Dieng Sarr,

Olushola Olorunnipa,

Stephen J. Popper,

Aïssatou GuèyeNdiaye,

Ibrahima Traoré,

M. Dia,

Souleymane Mboup,

Phyllis Kanki

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/507042

Subject(s) - seroconversion , antibody , immunology , viral disease , virology , disease , immunopathology , virus , medicine , human immunodeficiency virus (hiv) , viral replication , biology

The Tat protein of human immunodeficiency virus (HIV) is essential for viral replication and has extracellular pathogenic activity. We sought to determine whether the anti-Tat antibody response was predictive of disease progression in 144 HIV type 2 (HIV-2)-infected subjects observed longitudinally between 1985 and 2003. Sixty-eight percent of the subjects tested positive for anti-Tat antibodies, with reactivity notably established early after seroconversion and stably maintained over the course of infection. The risk and rate of progression to advanced HIV-2 AIDS was significantly higher in anti-Tat-negative subjects than in anti-Tat-positive subjects, extending the importance of this prognostic marker for HIV-2 AIDS.

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