A Novel Copper–Hydrogen Peroxide Formulation for Prion Decontamination | Zendy

Jérôme Solassol | Zendy; Manuela Pastore | Zendy; Carole Crozet | Zendy; Véronique Perrier | Zendy; Sylvain Lehmann | Zendy

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A Novel Copper–Hydrogen Peroxide Formulation for Prion Decontamination

Author(s) -

Jérôme Solassol,

Manuela Pastore,

Carole Crozet,

Véronique Perrier,

Sylvain Lehmann

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/506947

Subject(s) - human decontamination , scrapie , hydrogen peroxide , infectivity , prion protein , virology , bioassay , copper , chemistry , prion proteins , transmissible spongiform encephalopathy , creutzfeldt jakob syndrome , biology , microbiology and biotechnology , medicine , biochemistry , disease , pathology , virus , genetics , organic chemistry

With the appearance of variant Creutzfeldt-Jakob disease (CJD) and the detection of infectious prions in the peripheral organs of persons with sporadic CJD, the development of decontamination methods that are compatible with medical equipment has become a major issue. Here, we show that a formulation of copper metal ions in combination with hydrogen peroxide dramatically reduces the level of prion protein (PrP)(Sc) (the scrapie isoform of PrP) present in homogenates of samples from prion-infected brains, including brain samples from humans with CJD. An animal bioassay confirmed the reduction in prion infectivity, indicating that this novel Cu(2+)-H(2)O(2) formulation has great potential for prion decontamination.

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