A Multicenter Observational Study of the Potential Benefits of Initiating Combination Antiretroviral Therapy during Acute HIV Infection | Zendy

Frederick Hecht | Zendy; Lei Wang | Zendy; Ann C. Collier | Zendy; Susan J. Little | Zendy; Martin Markowitz | Zendy; Joseph B. Margolick | Zendy; J Michael Kilby | Zendy; Eric S. Daar | Zendy; Brian Conway | Zendy; Sarah Holte | Zendy

Open Access

A Multicenter Observational Study of the Potential Benefits of Initiating Combination Antiretroviral Therapy during Acute HIV Infection

Author(s) -

Frederick Hecht,

Lei Wang,

Ann C. Collier,

Susan J. Little,

Martin Markowitz,

Joseph B. Margolick,

J Michael Kilby,

Eric S. Daar,

Brian Conway,

Sarah Holte

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/506616

Subject(s) - medicine , discontinuation , seroconversion , viral load , confidence interval , cohort study , cohort , sida , observational study , antiretroviral therapy , immunology , viral disease , gastroenterology , human immunodeficiency virus (hiv)

Uncontrolled studies have suggested a benefit, after treatment discontinuation, of initiating highly active antiretroviral therapy (HAART) during primary human immunodeficiency virus (HIV) infection. We assessed whether initiation of HAART within 2 weeks of (acute treatment) or between 2 weeks and 6 months after (early treatment) HIV seroconversion was associated with improvements in the viral load and the CD4+ T cell count after discontinuation of treatment in an observational cohort.

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