New Drugs for Clostridium difficile Infection | Zendy

J. G. Bartlett | Zendy

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New Drugs for Clostridium difficile Infection

Author(s) -

J. G. Bartlett

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/506387

Subject(s) - medicine , metronidazole , vancomycin , clostridium difficile , colitis , disease , antibiotics , surgery , intensive care medicine , gastroenterology , microbiology and biotechnology , genetics , bacteria , staphylococcus aureus , biology

or persistent disease, to give oral metron- idazole or oral vancomycin. Prior expe- rience with these drugs shows that they are generally effective for acute disease, but treatment is often complicated by recur- rences after treatment. Our experience with 189 patients, including 100 with en- doscopy-proven pseudomenbraneous co- litis, showed that 96% of the patients re- sponded to oral vancomycin, but 24% experienced relapses when vancomycin therapy was discontinued (5). Other stud- ies have reported a similar experience (6).

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