Open AccessStaphylococcus aureusNasal Carriage Is Associated with Glucocorticoid Receptor Gene Polymorphisms
Author(s) -
Erica L. T. van den Akker,
Jan Nouwen,
Damian C. Melles∗,
Elisabeth F. C. van Rossum,
Jan W. Koper,
André G. Uitterlinden,
Albert Hofman,
Henri A. Verbrugh,
Huibert A. P. Pols,
Steven W. J. Lamberts,
Alex van Belkum
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/506367
Subject(s) - staphylococcus aureus , carriage , genotype , glucocorticoid , glucocorticoid receptor , allele , biology , gene , medicine , immunology , microbiology and biotechnology , genetics , pathology , bacteria
The aim of this study was to determine whether polymorphisms of the glucocorticoid receptor gene, influencing glucocorticoid sensitivity, are associated with persistent nasal carriage of Staphylococcus aureus. Two nasal swab cultures were obtained from each of 2,929 participants. Subjects were classified as persistent carriers (n=563) if both cultures were positive. GG homozygotes of the exon 9beta polymorphism were associated with a 68% reduced risk of persistent S. aureus nasal carriage, whereas carriers of the codon 23 lysine allele displayed an 80% increased risk. Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization.
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