Evidence That Intermittent Structured Treatment Interruption, but Not Immunization with ALVAC‐HIV vCP1452, Promotes Host Control of HIV Replication: The Results of AIDS Clinical Trials Group 5068 | Zendy

Jeffrey M. Jacobson | Zendy; R. Pat Bucy | Zendy; John Spritzler | Zendy; Michael S. Saag | Zendy; Joseph J. Eron | Zendy; Robert W. Coombs | Zendy; Rui Wang | Zendy; Lawrence Fox | Zendy; Victoria A. Johnson | Zendy; Susan CuUvin | Zendy; Susan E. Cohn | Zendy; Donna Mildvan | Zendy; Dorothy O’Neill | Zendy; Jennifer Janik | Zendy; Lynette Purdue | Zendy; Deborah K. O’Connor | Zendy; Christine Di Vita | Zendy; Ian Frank | Zendy

Open Access

Evidence That Intermittent Structured Treatment Interruption, but Not Immunization with ALVAC‐HIV vCP1452, Promotes Host Control of HIV Replication: The Results of AIDS Clinical Trials Group 5068

Author(s) -

Jeffrey M. Jacobson,

R. Pat Bucy,

John Spritzler,

Michael S. Saag,

Joseph J. Eron,

Robert W. Coombs,

Rui Wang,

Lawrence Fox,

Victoria A. Johnson,

Susan CuUvin,

Susan E. Cohn,

Donna Mildvan,

Dorothy O’Neill,

Jennifer Janik,

Lynette Purdue,

Deborah K. O’Connor,

Christine Di Vita,

Ian Frank

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/506364

Subject(s) - viral load , medicine , immunization , immunology , viral replication , immunity , clinical trial , virology , randomized controlled trial , vaccination , human immunodeficiency virus (hiv) , virus , immune system

The ability to control human immunodeficiency virus (HIV) replication in vivo in the absence of antiretroviral therapy (ART) is a measure of the efficiency of antiviral immunity. In a study of patients with chronic, ART-suppressed HIV infection, AIDS Clinical Trials Group 5068 investigated the effects of immunization with an exogenous HIV vaccine and pulse exposure to the subject's unique viral epitopes, by means of structured treatment interruptions (STIs), on the dynamics of viral rebound during a subsequent analytical treatment interruption (ATI).

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