Parvovirus B19 Empty Capsids as Antigen Carriers for Presentation of Antigenic Determinants of Dengue 2 Virus | Zendy

Georgios Amexis | Zendy; Neal S. Young | Zendy

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Parvovirus B19 Empty Capsids as Antigen Carriers for Presentation of Antigenic Determinants of Dengue 2 Virus

Author(s) -

Georgios Amexis,

Neal S. Young

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/506361

Subject(s) - virology , dengue fever , epitope , capsid , dengue virus , antigen , titer , parvovirus , biology , virus , recombinant dna , immunization , neutralization , antibody dependent enhancement , immunology , biochemistry , gene

For the production of dengue-vaccine candidates, empty capsids, or virus-like particles (VLPs), of parvovirus B19 that carry dengue 2-specific epitopes were employed as antigen carriers. Two epitopes (comprising amino acids 352-368 and 386-397) of domain BIII of the envelope glycoprotein were chosen to produce recombinant B19 VLPs for immunization of BALB/c mice. Serum samples from immunized mice revealed that recombinant B19 VLPs elicited strong humoral immune responses. In summary, this B19 VLP-vaccine platform produced high (> or =2.0 x 10(5)) anti-dengue 2 titers and robust (< or =1 120) 50%-plaque-reduction neutralization test (PRNT(50)) titers, which effectively neutralized live dengue 2 virus in PRNT(50) assays.

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