Prospective, Randomized Inpatient Study of Oral Metronidazole versus Oral Metronidazole and Rifampin for Treatment of Primary Episode ofClostridium difficile–Associated Diarrhea | Zendy

Danny D Lagrotteria | Zendy; Serena Holmes | Zendy; Marek Smieja | Zendy; Fiona Smaill | Zendy; Christine U. Lee | Zendy

Open Access

Prospective, Randomized Inpatient Study of Oral Metronidazole versus Oral Metronidazole and Rifampin for Treatment of Primary Episode ofClostridium difficile–Associated Diarrhea

Author(s) -

Danny D Lagrotteria,

Serena Holmes,

Marek Smieja,

Fiona Smaill,

Christine U. Lee

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/506354

Subject(s) - metronidazole , medicine , clostridium difficile , diarrhea , antibiotics , microbiology and biotechnology , biology

To date, no randomized trial to address the use of adjunctive rifampin in addition to metronidazole for the treatment of Clostridium difficile-associated diarrhea has been reported. Rifampin has excellent in vitro activity against C. difficile and penetrates into cellular materials where the organisms may persist.

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