Live Vaccine Strain Francisella tularensis Is Detectable at the Inoculation Site but Not in Blood after Vaccination against Tularemia | Zendy

Matthew J. Hepburn | Zendy; B K Purcell | Zendy; James V. Lawler | Zendy; S. R. Coyne | Zendy; Patricia L. Petitt | Zendy; K. D. Sellers | Zendy; David Norwood | Zendy; Melanie Ulrich | Zendy

Open Access

Live Vaccine Strain Francisella tularensis Is Detectable at the Inoculation Site but Not in Blood after Vaccination against Tularemia

Author(s) -

Matthew J. Hepburn,

B K Purcell,

James V. Lawler,

S. R. Coyne,

Patricia L. Petitt,

K. D. Sellers,

David Norwood,

Melanie Ulrich

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/506348

Subject(s) - francisella tularensis , tularemia , medicine , vaccination , attenuated vaccine , inoculation , blood culture , virology , microbiology and biotechnology , immunology , biology , virulence , antibiotics , biochemistry , gene

Live vaccine strain (LVS) Francisella tularensis is a live, attenuated investigational tularemia vaccine that has been used by the US Army for decades to protect laboratory workers. Postvaccination bacterial kinetic characteristics of LVS at the inoculation site and in the blood are unknown and, therefore, were assessed in a prospective study. LVS vaccination of laboratory workers provided the opportunity to compare culture with polymerase chain reaction (PCR) for the detection of F. tularensis in human clinical samples.

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