Low CD4+T Cell Nadir Is an Independent Predictor of Lower HIV‐Specific Immune Responses in Chronically HIV‐1–Infected Subjects Receiving Highly Active Antiretroviral Therapy | Zendy

M. Atif Siddique | Zendy; Kelly E. Hartman | Zendy; Ella Dragileva | Zendy; Marla Dondero | Zendy; Tebeb Gebretsadik | Zendy; Ayumi Shintani | Zendy; Larry Peiperl | Zendy; Fred Valentine | Zendy; Spyros A. Kalams | Zendy

Open Access

Low CD4⁺T Cell Nadir Is an Independent Predictor of Lower HIV‐Specific Immune Responses in Chronically HIV‐1–Infected Subjects Receiving Highly Active Antiretroviral Therapy

Author(s) -

M. Atif Siddique,

Kelly E. Hartman,

Ella Dragileva,

Marla Dondero,

Tebeb Gebretsadik,

Ayumi Shintani,

Larry Peiperl,

Fred Valentine,

Spyros A. Kalams

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/505913

Subject(s) - viremia , immunology , immune system , immunopathology , cd8 , t cell , viral load , lentivirus , viral disease , virology , nadir , antiretroviral therapy , medicine , virus , biology , satellite , engineering , aerospace engineering

The influence of CD4(+) T cell nadirs on human immunodeficiency virus (HIV)-specific immune responses in subjects with apparently normal CD4(+) T cell counts is not known. We evaluated the frequency of HIV-1-specific immune responses in a cohort of patients with complete viral suppression (HIV-1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had a wide range of CD4(+) T cell nadirs. We found positive associations between CD4(+) T cell nadirs and the magnitude of HIV-specific CD8(+) T cell responses (P=.02) and of T cell helper responses (P=.04). These data show the CD4(+) T cell nadir to be an independent predictor of HIV-specific CD4(+) and CD8(+) T cell responses in HIV-1-infected subjects with optimal suppression of viremia.

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