Open AccessCellular Immune Responses to Diluted and Undiluted Aventis Pasteur Smallpox Vaccine
Author(s) -
Michael T. Rock,
Sandra Yoder,
Thomas R. Talbot,
Kathryn M. Edwards,
James E. Crowe
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/505506
Subject(s) - vaccinia , immune system , immunization , reactogenicity , virology , vaccination , smallpox vaccine , immunology , biology , cellular immunity , cd8 , memory t cell , biochemistry , gene , recombinant dna
Recent primary vaccine trials of diluted Aventis Pasteur smallpox vaccine (APSV) demonstrated that immunization "take" rates, defined by the presence of a vesicle or pustule ("take") at the inoculation site 6-11 days after immunization, did not differ between the dilution groups. To our knowledge, there have been no studies that examine the cellular immune response or that distinguish CD4(+) T cell responses from CD8(+) T cell responses after primary immunization with varying dilutions of APSV.
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