Common Polymorphisms of Toll‐Like Receptors 4 and 9 Are Associated with the Clinical Manifestation of Malaria during Pregnancy | Zendy

Frank P. Mockenhaupt | Zendy; Lutz Hamann | Zendy; Christiane von Gaertner | Zendy; George BeduAddo | Zendy; Cordula von Kleinsorgen | Zendy; Ralf R. Schumann | Zendy; Ulrich Bienzle | Zendy

Open Access

Common Polymorphisms of Toll‐Like Receptors 4 and 9 Are Associated with the Clinical Manifestation of Malaria during Pregnancy

Author(s) -

Frank P. Mockenhaupt,

Lutz Hamann,

Christiane von Gaertner,

George BeduAddo,

Cordula von Kleinsorgen,

Ralf R. Schumann,

Ulrich Bienzle

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/505152

Subject(s) - malaria , plasmodium falciparum , tlr9 , tlr4 , pregnancy , immunology , toll like receptor , biology , receptor , medicine , innate immune system , immune system , gene , genetics , gene expression , dna methylation

Toll-like receptors (TLRs) are involved in recognition of and response to Plasmodium falciparum. In 304 primiparous Ghanaian women, we examined whether common TLR4 and TLR9 polymorphisms influence susceptibility to and manifestation of malaria during pregnancy. The TLR variants did not affect P. falciparum prevalence or parasite density. However, in P. falciparum-infected women, both the TLR4 Asp299Gly and the TLR9 T-1486C polymorphisms increased the risk of low birth weight in term infants 6-fold, and, additionally, TLR4 Asp299Gly increased the risk of maternal anemia 5-fold; preterm delivery was not associated with these TLR variants. These findings suggest that TLR4 and TLR9 play a role in the manifestation of malaria during pregnancy.

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