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Live oral rhesus-rhesus-human rotavirus reassortant tetravalent (RRV-TV) vaccine was efficacious against rotavirus gastroenteritis but was withdrawn because of a rare association with intussusception. A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine‐Human (UK) and Rhesus–Rhesus‐Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children