Antifolate Resistance inPlasmodium falciparum:Multiple Origins and Identification of NoveldhfrAlleles | Zendy

Andrea M. McCollum | Zendy; Amanda Poe | Zendy; Mary J. Hamel | Zendy; Curtis S. Huber | Zendy; Zhiyong Zhou | Zendy; Ya Ping Shi | Zendy; Peter Ouma | Zendy; John Vulule | Zendy; Peter Bloland | Zendy; Laurence Slutsker | Zendy; John W. Barnwell | Zendy; Venkatachalam Udhayakumar | Zendy; Ananías A. Escalante | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antifolate Resistance inPlasmodium falciparum:Multiple Origins and Identification of NoveldhfrAlleles

Author(s) -

Andrea M. McCollum,

Amanda Poe,

Mary J. Hamel,

Curtis S. Huber,

Zhiyong Zhou,

Ya Ping Shi,

Peter Ouma,

John Vulule,

Peter Bloland,

Laurence Slutsker,

John W. Barnwell,

Venkatachalam Udhayakumar,

Ananías A. Escalante

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/504687

Subject(s) - plasmodium falciparum , allele , virology , biology , antifolate , identification (biology) , malaria , genetics , drug resistance , immunology , gene , chemotherapy , antimetabolite , botany

Sulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype (51I/59R/108N) may have been generated as a single event in Southeast Asia, with subsequent spread of the single lineage to the African continent, but this hypothesis needs further validation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research