Mechanisms of Multidrug Resistance in Acinetobacter Species and Pseudomonas aeruginosa | Zendy

Robert A. Bonomo | Zendy; Dóra Szabó | Zendy

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Mechanisms of Multidrug Resistance in Acinetobacter Species and Pseudomonas aeruginosa

Author(s) -

Robert A. Bonomo,

Dóra Szabó

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/504477

Subject(s) - pseudomonas aeruginosa , efflux , microbiology and biotechnology , aminoglycoside , multiple drug resistance , antibiotics , acinetobacter baumannii , antibiotic resistance , acinetobacter , gene , bacterial outer membrane , biology , medicine , bacteria , genetics , escherichia coli

Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

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