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To the Editor—It has been suggested that 5%–20% of brain abscesses are presumably associated with oral infections or dental procedures [1–4], in which organisms belonging to the oropharyngeal flora, such as Arcanobacterium haemolyticum, are involved [5, 6]. This organism has been documented in cases of pharyngitis and wound infections [7], but rarely in systemic infections [7–9] and even less in brain abscesses [10]. We describe the case of a patient who developed a brain abscess due to A. haemolyticum infection after undergoing dental extraction procedure. An 18-year-old man without a remarkable medical history, except for repeated periodontal manipulations, was admitted to the hospital with headache, vomiting, aphasia, weakness in his left extremities, behavior and mood alterations, and fever. Three months before admission, he had been treated for periodontitis and dental caries in a primary dental clinic. He underwent extraction of multiple teeth. He had been well until 15 days before hospital admission, when intense headache and vomiting developed. Seven days before hospitalization, weakness in his left extremities became worse, and he was unable to stand or walk. A brain CT scan revealed a left-sided hypodense fronto-parietal lesion with cystic, contrast ring enhancement and perilesional edema exerting a significant mass effect (a 1.8-cm displacement of the middle line). He was referred to our hospital and was admitted to a neurosurgical ward. On admission to the neurosurgical ward, he was afebrile. His blood pressure was 140/80 mmHg, his respiratory rate was 14 breaths per min, his heart rate was 82 beats per min, and his temperature was 36.6 C. He was conscious and alert. Neurologic examination revealed no evidence of neck stiffness or of Kernig’s or Brudzinski’s signs. Muscle strength was 3/5 in his left leg muscle and in his left forearm muscle. Laboratory data included a peripheral WBC count of cells/L with 88% neutro9 19.02 10 phils, a hemoglobin level of 13.3 g/dL, a platelet count of platelets/L, 9 304 10 and an erythrocyte sedimentation rate of 10 mm/h. His aspartate aminotransferase, alanine aminotransferase, anaplastic lymphoma kinase, creatinine, blood glucose, plasma sodium, and plasma potassium levels were normal. Subaracnoid hemorrhage was suspected as the likely diagnosis. He was treated with supportive care, but continued to complain of symptoms he had at admission. On his second day in the hospital, he complained of severe headache, and his mental state abruptly became worse, with the onset of confusion and anisocoric pupils. His Glasgow coma score was 10/15. An emergency left-sided craniotomy was performed, with aspiration of an encapsulated mass containing white-yellowish pus (150 mL). The pathological diagnosis was a brain abscess. Immediately after surgery, the patient was treated with ceftriaxone (2 g every 24 h intravenously) and metronidazole (500 mg every 8 h intravenously). The day after surgery, the patient’s mental status returned to nearly normal (Glasgow coma score of 13/15), and he no longer complained of headache. The weakness in his left extremities improved significantly. Microscopic observation of the Gram stained smear of the abscess sample showed pleomorphic gram-positive coryneform bacteria. After 48 h at 37 C, aerobic culture grew minute, translucent, nonpigmented colonies with a small zone of clear hemolysis on 5% sheep blood agar. On the basis of the hemolytic pattern, a negative catalase reaction, and other biochemical test criteria, the isolate was identified as A. haemolyticum [11]. The isolate was found to be susceptible to penicillin, ceftriaxone, gentamicin, clindamicin, doxicicline, and vancomicin, but resistant to trimethoprim-sulfamethoxazole and ciprofloxacin by disk diffusion method. From the seventh day post-surgery, the patient received penicillin G (24 mU intravenously, daily for 21 days). Four weeks later, the patient was successfully discharged from the hospital with no subsequent complications. A. haemolyticum is a catalase-negative, gram-positive, or gram-variable rod whose morphology is dependent on the growth media and conditions [11]. This species (formerly Corynebacterium haemolyticum) is an infrequent cause of pharyngitis in children and young adults. It is occasionally isolated from wound infections and abscesses and is found in patients with meningitis, pneumonia, pyothorax, and septicemia [7–13]. To our knowledge, after a review of the indexed literature, we consider this to be the second reported case in which A. haemolyticum is documented as the etiological agent of a brain abscess (previously, 1 case in a child was reported) [10] and the first in an adult patient. Although A. haemolyticum is susceptible (thus far, universally) to penicillin by in vitro MIC testing, treatment failure despite adequate doses of phenoxymethylpenicillin has been documented [11, 13–15]. Most studies have found that A. haemolyticum is susceptible to all antimicrobials tested, except trimethoprim-sulfamethoxazole [11, 13–16]. In the current case, the isolate was also resistant to ciprofloxacin. This case illustrates the aggressive and serious nature of systemic odontogenic infections in which resistant strains could be producing severe neurological complications. The careful identification of Arcanobacterium species and its corresponding antimicrobial susceptibility test is important, so a complete understanding of the role of these organisms in disease and proper management can be realized [17]. As was seen in our case, A. haemolyticum can be resistant to additional drugs other than trimethoprim-sulfamethoxazole (ciprofloxacin, in this report) and can cause severe life-threatening diseases.

Brain Abscess Due to Arcanobacterium haemolyticum after Dental Extraction