Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference | Zendy

Thomas W. Geisbert | Zendy; Lisa E. Hensley | Zendy; Elliott Kagan | Zendy; Erik Z. Yu | Zendy; Joan B. Geisbert | Zendy; Kathleen M. Daddario-DiCaprio | Zendy; Elizabeth A. Fritz | Zendy; Peter B. Jahrling | Zendy; Kevin McClintock | Zendy; Janet R. Phelps | Zendy; Amy C. H. Lee | Zendy; Adam D. Judge | Zendy; Lloyd B. Jeffs | Zendy; Ian MacLachlan | Zendy

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Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference

Author(s) -

Thomas W. Geisbert,

Lisa E. Hensley,

Elliott Kagan,

Erik Z. Yu,

Joan B. Geisbert,

Kathleen M. Daddario-DiCaprio,

Elizabeth A. Fritz,

Peter B. Jahrling,

Kevin McClintock,

Janet R. Phelps,

Amy C. H. Lee,

Adam D. Judge,

Lloyd B. Jeffs,

Ian MacLachlan

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/504267

Subject(s) - ebola virus , virology , rna interference , small interfering rna , virus , biology , viral replication , rna , gene , genetics

Ebola virus (EBOV) infection causes a frequently fatal hemorrhagic fever (HF) that is refractory to treatment with currently available antiviral therapeutics. RNA interference represents a powerful, naturally occurring biological strategy for the inhibition of gene expression and has demonstrated utility in the inhibition of viral replication. Here, we describe the development of a potential therapy for EBOV infection that is based on small interfering RNAs (siRNAs).

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