Open AccessAssociation between the Replication Capacity and Mother‐to‐Child Transmission of HIV‐1, in Antiretroviral Drug–Naive Malawian Women
Author(s) -
Susan H. Eshleman,
Yolanda Lie,
Donald R. Hoover,
Shu Chen,
Sarah E. Hudelson,
Susan A. Fiscus,
Christos J. Petropoulos,
Johnstone Kumwenda,
Neil Parkin,
Taha E. Taha
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/503810
Subject(s) - nevirapine , zidovudine , transmission (telecommunications) , antiretroviral drug , replication (statistics) , virology , odds ratio , confidence interval , medicine , viral replication , immunology , viral load , human immunodeficiency virus (hiv) , biology , antiretroviral therapy , viral disease , virus , electrical engineering , engineering
Replication capacity and transmission of human immunodeficiency virus (HIV)-1 in antiretroviral drug-naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV-1 and in 47 women whose infants were uninfected by 6-8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters (P=.01). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11-1.90]; P = .0063), after adjustment for maternal HIV-1 load and other factors.
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