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Use of heptavalent protein-polysaccharide pneumococcal conjugate vaccine (PCV7) has been associated with decreases in PCV7-type invasive pneumococcal disease and nasopharyngeal (NP) carriage in children. Vaccine use has also indirectly decreased the rate of invasive disease in adults, presumably through decreased transmission of pneumococci from vaccinated children to adults.

Indirect Effect of Conjugate Vaccine on Adult Carriage ofStreptococcus pneumoniae:An Explanation of Trends in Invasive Pneumococcal Disease