Reduced Gene Expression of Intestinal α‐Defensins Predicts Diarrhea in a Cohort of African Adults | Zendy

Paul Kelly | Zendy; Mona BajajElliott | Zendy; Max Katubulushi | Zendy; Isaac Zulu | Zendy; Richard Poulsom | Zendy; Roger A. Feldman | Zendy; Charles Bevins | Zendy; Winnie Dhaliwal | Zendy

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Reduced Gene Expression of Intestinal α‐Defensins Predicts Diarrhea in a Cohort of African Adults

Author(s) -

Paul Kelly,

Mona BajajElliott,

Max Katubulushi,

Isaac Zulu,

Richard Poulsom,

Roger A. Feldman,

Charles Bevins,

Winnie Dhaliwal

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/503747

Subject(s) - diarrhea , biology , defensin , interquartile range , cohort , gene expression , biopsy , in situ hybridization , immunology , medicine , gene , genetics

Human defensin (HD) 5 and HD6, both Paneth cell alpha-defensins, contribute to the antimicrobial barrier against intestinal infection. We have previously demonstrated that levels of both HD5 and HD6 mRNA were reduced in adults living in urban Zambia, compared with those in adults living in London. The aim of the present study was to determine, during 2 years of follow-up, whether alpha-defensin expression in Zambian adults is related to susceptibility to diarrhea.

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