Nucleic Acid Testing for West Nile Virus RNA in Plasma Enhances Rapid Diagnosis of Acute Infection in Symptomatic Patients | Zendy

Peter Tilley | Zendy; Julie D. Fox | Zendy; Gayatri Jayaraman | Zendy; Jutta K. Preiksaitis | Zendy

Open Access

Nucleic Acid Testing for West Nile Virus RNA in Plasma Enhances Rapid Diagnosis of Acute Infection in Symptomatic Patients

Author(s) -

Peter Tilley,

Julie D. Fox,

Gayatri Jayaraman,

Jutta K. Preiksaitis

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/503577

Subject(s) - serology , viremia , virology , medicine , nucleic acid , west nile virus , nucleic acid test , antibody , nucleic acid amplification tests , virus , biology , immunology , covid-19 , infectious disease (medical specialty) , disease , biochemistry , chlamydia trachomatis

Although nucleic acid amplification testing (NAAT) for West Nile virus (WNV) is useful in screening blood donors, such methods have not been studied in symptomatic patients. For diagnosis of WNV infection, 1.0 mL of plasma was tested by NAAT, and WNV-specific immunoglobulin M was assayed. Of 276 WNV cases, 191 were tested by both serology and NAAT. Of these, 86 (45.0%), 111 (58.1%), and 180 (94.2%) were detected by NAAT, serology, and combined NAAT and serology, respectively. NAAT-based screening was most useful within 8 days of the onset of symptoms. Viremia is common in early symptomatic WNV infection, and NAAT enhances diagnostic yield.

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