The Poor Prognosis of Central Nervous System Cryptococcosis among Nonimmunosuppressed Patients: A Call for Better Disease Recognition and Evaluation of Adjuncts to Antifungal Therapy | Zendy

İsmail Zafer Ecevit | Zendy; Cornelius J. Clancy | Zendy; Ilona M. Schmalfuss | Zendy; M. Hong Nguyen | Zendy

Open Access

The Poor Prognosis of Central Nervous System Cryptococcosis among Nonimmunosuppressed Patients: A Call for Better Disease Recognition and Evaluation of Adjuncts to Antifungal Therapy

Author(s) -

İsmail Zafer Ecevit,

Cornelius J. Clancy,

Ilona M. Schmalfuss,

M. Hong Nguyen

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/503570

Subject(s) - medicine , cryptococcosis , antifungal , disease , central nervous system , intensive care medicine , immune system , mycosis , immunology , dermatology

We describe 9 nonimmunosuppressed patients with central nervous system cryptococcosis. Morbidity and mortality were high, especially among patients with cerebral infarcts. This was attributed to delayed diagnosis and apparent sequelae of overwhelming host immune responses. We present clues suggesting the diagnosis. Increased recognition and timely diagnosis of this condition may improve outcomes.

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