Resistance to Antimony and Treatment Failure in HumanLeishmania (Viannia)Infection | Zendy

Ricardo Rojas | Zendy; Liliana Valderrama | Zendy; Mabel Valderrama | Zendy; Maria X. Varona | Zendy; Marc Ouellette | Zendy; Nancy Gore Saravia | Zendy

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Resistance to Antimony and Treatment Failure in HumanLeishmania (Viannia)Infection

Author(s) -

Ricardo Rojas,

Liliana Valderrama,

Mabel Valderrama,

Maria X. Varona,

Marc Ouellette,

Nancy Gore Saravia

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/503371

Subject(s) - leishmania , antimony , virology , acquired resistance , microbiology and biotechnology , leishmaniasis , biology , resistance (ecology) , drug resistance , medicine , immunology , parasite hosting , chemistry , ecology , world wide web , computer science , inorganic chemistry

Failure of antimonial therapy has been increasingly reported in anthroponotic visceral leishmaniasis and in cutaneous disease. The role of drug resistance in treatment failure has been difficult to ascertain because therapeutic response is multifactorial, and the efficacy of antimonial drugs depends on an effective immune response. In this study, we sought to determine whether standard treatment selects for resistant organisms and whether drug resistance contributes to treatment failure.

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