In Vivo Development of Ertapenem Resistance in a Patient with Pneumonia Caused by Klebsiella pneumoniae with an Extended-Spectrum -Lactamase | Zendy

Eugenne Elliott | Zendy; Adrian Brink | Zendy; Johan van Greune | Zendy; Z. Els | Zendy; Neil Woodford | Zendy; Jane F. Turton | Zendy; Morgyn S. Warner | Zendy; D. M. Livermore | Zendy

Open Access

In Vivo Development of Ertapenem Resistance in a Patient with Pneumonia Caused by Klebsiella pneumoniae with an Extended-Spectrum -Lactamase

Author(s) -

Eugenne Elliott,

Adrian Brink,

Johan van Greune,

Z. Els,

Neil Woodford,

Jane F. Turton,

Morgyn S. Warner,

D. M. Livermore

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/503264

Subject(s) - ertapenem , klebsiella pneumoniae , microbiology and biotechnology , klebsiella pneumonia , in vivo , medicine , pneumonia , porin , beta lactamase , enterobacteriaceae , antibiotics , antibiotic resistance , imipenem , bacteria , biology , pseudomonas aeruginosa , escherichia coli , bacterial outer membrane , gene , biochemistry , genetics

Four sequential extended-spectrum beta -lactamase-producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research