Vascular Leakage in Severe Dengue Virus Infections: A Potential Role for the Nonstructural Viral Protein NS1 and Complement | Zendy

Panisadee Avirutnan | Zendy; Nuntaya Punyadee | Zendy; Sansanee Noisakran | Zendy; Chulaluk Komoltri | Zendy; Somchai Thiemmeca | Zendy; Kusuma Auethavornanan | Zendy; Aroonroong Jairungsri | Zendy; Rattiyaporn Kanlaya | Zendy; Nattaya Tangthawornchaikul | Zendy; Chunya Puttikhunt | Zendy; Sanga Pattanakitsakul | Zendy; Pathai Yenchitsomanus | Zendy; Juthathip Mongkolsapaya | Zendy; Watchara Kasinrerk | Zendy; Nopporn Sittisombut | Zendy; Matthias Husmann | Zendy; Maria Blettner | Zendy; Sirijitt Vasanawathana | Zendy; Sucharit Bhakdi | Zendy; Prida Malasit | Zendy

Open Access

Vascular Leakage in Severe Dengue Virus Infections: A Potential Role for the Nonstructural Viral Protein NS1 and Complement

Author(s) -

Panisadee Avirutnan,

Nuntaya Punyadee,

Sansanee Noisakran,

Chulaluk Komoltri,

Somchai Thiemmeca,

Kusuma Auethavornanan,

Aroonroong Jairungsri,

Rattiyaporn Kanlaya,

Nattaya Tangthawornchaikul,

Chunya Puttikhunt,

Sanga Pattanakitsakul,

Pathai Yenchitsomanus,

Juthathip Mongkolsapaya,

Watchara Kasinrerk,

Nopporn Sittisombut,

Matthias Husmann,

Maria Blettner,

Sirijitt Vasanawathana,

Sucharit Bhakdi,

Prida Malasit

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/500949

Subject(s) - anaphylatoxin , complement system , dengue fever , dengue virus , complement membrane attack complex , immunology , antibody , virology , lectin pathway , classical complement pathway , biology , medicine

Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown.

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