Inhibitor κB and Nuclear Factor κB in Granulocyte‐Macrophage Colony‐Stimulating Factor Antagonism of Dexamethasone Suppression of the Macrophage Response toAspergillus fumigatusConidia | Zendy

JungHyun Choi | Zendy; Elmer Brummer | Zendy; Young Jun Kang | Zendy; Patricia P. Jones | Zendy; David A. Stevens | Zendy

Open Access

Inhibitor κB and Nuclear Factor κB in Granulocyte‐Macrophage Colony‐Stimulating Factor Antagonism of Dexamethasone Suppression of the Macrophage Response toAspergillus fumigatusConidia

Author(s) -

JungHyun Choi,

Elmer Brummer,

Young Jun Kang,

Patricia P. Jones,

David A. Stevens

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/500948

Subject(s) - aspergillus fumigatus , antagonism , microbiology and biotechnology , macrophage , dexamethasone , aspergillus , biology , granulocyte macrophage colony stimulating factor receptor , immunology , macrophage colony stimulating factor , in vitro , biochemistry , endocrinology , receptor

The dexamethasone (DEX) immunosuppressive effect on macrophage killing activity and cytokine production in response to Aspergillus fumigatus conidia is antagonized by granulocyte-macrophage colony-stimulating factor (GM-CSF). The molecular mechanism is unknown. We postulated that this antagonism is mediated by inhibitor kappaB (I kappaB) induction by DEX and is opposed by acceleration of I kappaB degradation by GM-CSF with or without conidia stimulation, with corresponding effects on translocation and activation of nuclear factor kappa B (NF-kappaB).

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