Open AccessRecovery of Drug‐Resistant Influenza Virus from Immunocompromised Patients: A Case Series
Author(s) -
Michael G. Ison,
Larisa V. Gubareva,
Robert L. Atmar,
John J. Treanor,
Frederick G. Hayden
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/500465
Subject(s) - zanamivir , oseltamivir , neuraminidase , virology , virus , hemagglutinin (influenza) , neuraminidase inhibitor , drug resistance , influenza a virus , orthomyxoviridae , resistance mutation , influenzavirus b , mutation , biology , medicine , microbiology and biotechnology , gene , polymerase chain reaction , reverse transcriptase , covid-19 , genetics , infectious disease (medical specialty) , disease
Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.
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